Cell Death: The Role of PARP by Csaba Szabo

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Cell Death: The Role of PARP by Csaba Szabo

Cell Death: The Role of PARP by Csaba Szabo
English | June 22, 2000 | ISBN: 0849322677 | 354 Pages | PDF | 8 MB

Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression.
More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this enzyme, mediating a suicidal mechanism triggered by DNA strand breakage. This hypothesis has since become a controversial centerpiece of the PARP field, with many experimental systems both confirming and extending the PARP suicide theory.

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