Drug Discovery

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Drug Discovery
ed. by Hany A. El-Shemy
InTeOp | 2013 | ISBN: 9535109068 9789535109068 | 524 pages | PDF | 11 MB

This book on drug discovery will play vital role in the new era of disease treatment using natural products.
Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world.
Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years.
Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive.
1 FruityVegetable-Drug Interactions: Effects on Drug Metabolizing Enzymes and Drug Transporters
2 Anticancer Drug Discovery — From Serendipity to Rational Design
3 Drug Interactions, Pharmacogenomics and Cardiovascular Complication
4 Interactions with Drugs and Dietary Supplements Used For Weight Loss
5 Small Molecule Screens to Identify Inhibitors of Infectious Disease
6 Practical Considerations of Liquid Handling Devices in Drug Discovery
7 Data Analysis Approaches in High Throughput Screening
8 Oxidative Stress in Human Infectious Diseases - Present and Current Knowledge About Its Druggability
9 Discovery of Selective and Potent Inhibitors of Palmitoylation
10 The Antibacterial Drug Discovery
11 Air, Water and Soil: Resources for Drug Discovery
12 Transition State Analogues of Enzymatic Reaction as Potential Drugs
13 Suppression of Pro-Inflammatory Cytokines via Targeting of STAT-Responsive Genes
14 Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target
15 Colon Cancer: Current Treatments and Preclinical Models for the Discovery and Development of New Therapies
16 Applications of Snake Venom Proline-Rich Oligopeptides (Bj-PROs) in Disease Conditions Resulting from Deficient Nitric Oxide Production
17 Introduction to Biochemical Pharmacology and Drug Discovery

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